Ibuprofen-Loaded ZnO Nanoparticle/Polyacrylonitrile Nanofibers for Dual-Stimulus Sustained Release of Drugs

Based on the opportunities of ibuprofen administration innovation and challenges associated with construction transdermal drug delivery systems using medicated nanoparticles electrospun nanofiber membranes, we developed a system comprising ibuprofen-loaded ZnO nanoparticles/polyacrylonitrile membranes (ZnO-ibuprofen/PAN), which was dual-stimulus responsive, wherein both pH temperature triggered release. ZnO-ibuprofen high loading capacity (17.7%) were prepared at room by one-step method involving 4,4′-((4-(4H-1,2,4-triazol-4-yl) phenyl) azanediyl)dibenzoic acid, Zn(NO3)2·6H2O, ibuprofen, following electrospinning conducted to generate ZnO-ibuprofen/PAN nanofibers. The release behavior in normal (pH = 7.4, 37 °C) inflammatory 6.5, 42 tissue environment exhibited increased rate higher ambient temperatures decreased 24 h cumulative fibers through porcine skin under conditions reached 71.35% ± 2.96% after h, thereby demonstrating their favorable permeation behavior. cytotoxicity assays revealed that nanofibers possessed excellent biocompatibility. Thus, dual stimulus-responsive can be an effective carrier.